<日本語/English>食物栄養学科 土生敏行准教授が、科学雑誌『FASEB BIOADVANCES』において、2021-2022年の間に出された論文の中で最も引用された「Top cited article」として表彰されました。


食物栄養学科 土生敏行准教授が、科学雑誌『FASEB BIOADVANCES』において、2021-2022年の間に出された論文中、最も引用された「Top cited article」として表彰されました。


最も引用された論文は、土生准教授が筆頭、責任著者である「UBC13 is an RNF213-associated E2 ubiquitin-conjugating enzyme, and Lysine 63-linked ubiquitination by the RNF213-UBC13 axis is responsible for angiogenic activity」(共同研究者は京都大学大学院医学研究科 社会健康医学系専攻環境衛生学分野 原田浩二准教授)。日本でも発症が多い「もやもや病」の原因因子に関する研究です。






Associate Professor Toshiyuki Habu of the Department of Food and Nutrition received an award in the scientific journal "FASEB BIOADVANCES" .


"UBC13 is an RNF213-associated E2 ubiquitin-conjugating enzyme, and Lysine 63-linked ubiquitination by the RNF213- UBC13 axis is responsible for angiogenic activity" (co-researcher: Associate Professor Kouji Harada, Department of Environmental Health and Sciences, Division of Social and Health Medicine, Graduate School of Medicine, Kyoto University) was the most cited "Top cited article" among articles published during the period 2021-2022. This is a study on the causative factors of moyamoya disease, which is a common disease in Japan.


Moyamoya disease is a common disease in East Asia, especially in Japan, Korea, and China, with an approximate frequency of 1 per 10,000 people in Japan, most commonly in women, and presents as cerebral hemorrhage or stroke. Our research group has shown that a polymorphism (p.R4810K), in which arginine replaces lysine at position 4810 of the enzyme encoded by the RNF213 gene, is shared in affected families as a causative factor. However, the function of the enzyme has not been clarified. In this study, the factors that influence the nature of the enzyme and its effect on vascular cells were identified," he explained.


Upon receiving the award, he said, “Moyamoya disease is a designated intractable disease and relies on surgical treatment. It is also related to other vascular diseases, and we believe that it will contribute to research in the field of vascular diseases, and we expect to develop therapeutic drugs for vascular diseases," he said.



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